When benign (noncancerous) tumors of either Schwannoma or, Meningioma grows in the brain from; Neurofibromatosis Type 2 (NF2), or from spontaneous tumor development; tumor growth is typically slow, at a rate of 1mm a year. Exact rate of growth of tumor varies from person, and tumor by tumor in the same person for different reasons.
This slow growth allows the brain time to adjust to enlarging tumors. This can prevent brain trauma due to growth alone and be an advantage because expansion of tumors can occur for many years without requiring treatment.
Some of the problems that can occur include: 1) Rapid or Increased Growth Rate, 2) Surgery, 3) Radiation / Radiotherapy, 4) Clinical Trial Chemotherapy Molecular Targeted Tumor Therapy. The actual issue varies based on a tumor's location.
A variety of tumor types can grow in patients with NF2 and cause damage to the Central Nervous System (CNS) ; the brain and spinal cord. Tumors can also grow and cause damage in other areas. While the most common issues for individuals with NF2 involve Cranial Nerves, which are the nerves that branch out from the brainstem, other issues can develop including:
CSF is a clear and colorless fluid that needs to continuously move through a membrane that surrounds the Central Nervous System; brain and spinal cord. CSF needs to continuously flow from brain to spine and as tumor burden increases, where the flow stops can be fatal. There are warning signs that this is happening and different treatment options.
Tumor growth can cause issues with the necessary flow of Cerebrospinal Fluid (CSF) from the brain into the spine. There are two forms of Cerebrospinal-Fluid flow issues that might develop; Intracranial Pressure also known as Obstructive Hydrocephalus and CSF Leak also known as Intracranial Hypotension.
Epilepsy is a brain disorder in which a person has repeated seizures over time. Seizures are episodes of disturbed brain activity that cause changes in attention or behavior.
The likely causes of Epilepsy for individuals with NF2 include:
What is - A stroke occurs when the blood supply to the brain is interrupted or reduced. This deprives your brain of oxygen and nutrients, which can cause your brain cells to die.
A stroke may be caused by a blocked artery (ischemic stroke) or a leaking or burst blood vessel (hemorrhagic stroke). Some people may experience a temporary disruption of blood flow through their brain (transient ischemic attack, or TIA).
Symptoms of strokes can include; Trouble walking, Trouble speaking, Trouble understanding, sudden paralysis of face arm or leg, Trouble seeing in one or both eyes, severe headache, dizziness or nausea.
Cognitive problems, also referred to as cognitive dysfunction or "chemo brain," occur when a person has trouble processing information, which includes mental tasks related to attention span, thinking, and short-term memory.[ASCO, 2013]
Cognitive Issues are brain issues the result of brain cell damage and can differ depending on the regions of the brain the issue lies. People with NF2 are at risk to potentially develop Cognitive Issues but only as the result of brain trauma from; fast changing tumors, surgery, or radiation / radiotherapy treatments.
Cognitive issues from tumor growth can be temporary particularly if the result of tumor growth or surgery. Cognitive issues are more likely to not recover following radiation / radiotherapy treatments, particularly when used as a treatment for younger individuals.
There are two major regions of the brain Cerebellum and the four Lobes that make up the Cerebrum (aka Telencephalon). Each of these regions of the brain is responsible for different functions.
Some additional thing that could determine what is or is not affected includes damage to the following:
Men and women access different parts of their brains for the same tasks. Women's brains have more white matter. Men have more gray matter.
From birth the brain continues to develop and continues to do so while an individual encourages their brain to continue to learn. As people grow older this process slows down, believed to be at about the age of 18 - 20. However, an individual recovering from any brain trauma can be an opportunity to not just recover but to advance like in the need to learn a language due to hearing loss or the brain learning to work to understand how to with an Auditory Brainstem Implant (ABI).
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