Tumor Supressor - NF2 drugs and more

Last Updated: 09/15/17

  1. NF2 Inhibitors - Mechanism of Action
  2. Clinical Trials: Targeted Treatment
    • Drug-Based Treatments (all Clinical Trials)
    • Potential Future Clinical Trials
    • Determined Ineffective for NF2
  3. Dietary Phytochemicals (Botanicals)
    • Over The Counter (OTC)
    • Not Publicly Available
    • Additional Substances

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to becoming a tumor.

Currently, no treatment has been proven to be one-hundred percent (100%) effective to destroy NF2 tumors or even simply stop all NF2 tumor growth in any individual; however several are in different stages of Clinical Trials of Chemotherapy type treatments. The goal with the Clinical Trial options is to treat all tumors at once, and to date, there have been a few options that have been found to have some success with certain tumor types and none of the options available works for everyone with NF2.

The only primary method of treatment for NF2 tumors is different forms of Microsurgery (Traditional Surgery) including but not limited to complete or partial tumor removal. The problem with any of the surgical options is it can typically only allow for treatment of one tumor at a time. Inability to treat more than one tumor is a problem since it can take months to heal before more tumors can get treatment.

There are issues but occasional advantages to either Radiotherapy or Radiation treatment, however, there can be long-term consequences to these treatments. People with NF2 can have unique issues to these treatments, in comparison to people having Radiotherapy or Radiation Treatment for other reasons.(Please follow the link to understand advantages and disadvantages. )

It is difficult to determine the effectiveness of chemotherapy with a long-standing disease where individuals would already have had several treatments of other sorts that could cause conflicting data (Example of Radiotherapy or Radiation Treatments). Other chemotherapies and radiation therapies alone would affect how an individual responds to treatment. [Fathi,2013]

The lack of ability to treat all tumors with the primary treatment of surgery means a molecular treatment is likely the answer to the cure for NF2. As the MERLIN Protein is the reason for NF2 tumor growth, "Gene Therapy and other types of treatments where we actually restore normal MERLiN function seem to be a good way to restore all of these functions back to normal."[Asthagiri,2015]

1. Inhibitors - Mechanism of Action


2. Clinical Trials: Targeted Treatment

No treatment for NF2 has been found effective for all tumor types, or this section would be labeled, The Cure and since treatments at best sometimes alter one (1) tumor type, these treatments are called Targeted Tumor Therapies. Some of the treatments sometimes Schwannoma tumors in some individuals for a period and a trial to help treat Ependymoma has just been started which has not gone far enough into early stages to know if it has helped anyone at all.

3. Dietary Phytochemicals (Botanicals)

Dietary Phytochemicals, treatment of health with Phytotherapy is often called either Botanical Options or Natural Options individuals may consider trying in addition to regular medical care.

Botanical treatment options are things grown naturally which result in fewer or no side effect issues when taken long term, provided these things are eaten or taken in. Some do in fact have side effects when not taken in moderation, which can be difficult to determine when taken in pills or capsules.

The hope with these is that they can help slow down or stop growth. Options found here have proven to have the potential of tumor delay in NF2 or other Tumor Conditions.

Source

  1. Fathi, A. R., & Roelcke, U. (2013). "Meningioma. Current neurology and neuroscience reports, 13(4), 1-8. http://link.springer.com/article/10.1007/s11910-013-0337-4
  2. Asthagiri M.D. National Institute of Health and NF2 Research. University of Virginia. 2015 NF2 Ohio Gathering. (2015) Section 6. MERLIN part in current Trial Limits, Paragraph 2. http://nf2is.org/Ohio_Gathering2015.php