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Sirolimus

Last Updated: 01/18/18

Status: Potential NF2 Clinical Trial

Index

  1. Basic Information
  2. Clinical Trials
  3. Side Effects

1. Basic Description:

Sirolimus (INN/USAN), also known as Rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. Sirolimus is also a medication that has been in trial for NF2 tumors.

2. Unrelated Clinical Trials:

  • Efficacy of Sirolimus In Liver Transplantation for Hepatocellular Carcinoma (HCC) - www.ClinicalTrials.gov
  • A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis - www.ClinicalTrials.gov

3. Serious Side Effects:

  • Increase Risk of Infections or Cancer - Lymphoma (Cancer of the Immune System) and Skin Cancer
  • If you had Liver or Lung Transplants, may cause serious side effects or death

Common Side Effects:

  • Fever
  • Chills
  • Frequent or Painful Urination
  • Night Sweats
  • Chest Pain
  • General Pain
  • Constant Weakness or Tiredness
  • Fullness in the Stomach
  • Unexplained Weight Loss
  • Unusual Bleeding or Bruising
  • Skin Issues -
    • Sores
    • Swelling
    • Red Skin
    • Racked Skin
    • Hives
    • Rash
    • Itching
  • Throat Issues -
    • Trouble Breathing
    • Swallowing
    • Cough
    • Sore Throat
    • Hoarseness
  • Swelling -
    • Neck Glands
    • Armpits
    • Groin
    • Face
    • Throat
    • Tongue
    • Lips
    • Eyes
    • Hands
    • Feet
    • Ankles
    • Lower Legs
Edema, headache, fever, arterial hypertension, GI disorders, anemia, thrombocytopenia, hyperlipidemia, arthralgia, diabetes mellitus, infections

Additional Possible Side Effects:

  • Headache
  • Constipation
  • Diarhhea
  • Nausea
  • Joint Pain

Sources