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Everolimus (Afinitor™)

Last Updated: 01/18/18

Status: Currently a NF2 Clinical Trial

Chemical Structure, RAD001

Index

  1. Basic Facts
  2. Side Effects
  3. Other Uses

1. Basic Information

Other Names RAD-001, RAD001, Certican, Afinitor, Zortress, Sirolimus, SDZ-RAD, RAD001, Everolimus [USAN], RAD 001, Rapamycin, 42-O-(2-hydroxyethyl)-, UNII-9HW64Q8G6G
Trade Name Afinitor™ FermentekTM
Pharmaceutical Company Novartis
Tumor Target Vestibular Schwannoma
Treatment By Pill - Oral
NF2 Trials
Inhibitor mTOR Inhibitors (Mammalian Target of Rapamycin), effect is solely mTORC1 protein and not mTORC2 protein, similar to Sirolimus
Molecular Formula C53H83NO14
IUPAC Name dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Prescription Information DailyMed
PubChem CID 6442177
ChemSpider 21106307

2. Side Effects

Common Side Effects

  • Lung and Breathing Problems
  • Infections
  • Kidney Failure
  • Mouth Ulcers
  • Liver problems
  • Vaccinations - patients should not have live vaccinations while on Afinitor
  • Contraindicated with certain medications and certain foods

Additional Possible Side Effects:

  • Mouth Ulcers
  • Feeling Weak
  • Cough
  • Shortness of Breath
  • Diarrhea
  • Rash, Dry Skin, Itching
  • Nausea and Vomiting
  • Fever
  • Loss of Appetite
  • Swelling - Arms, Legs, Feet or Ankles
  • Infections - Respiratory Tract, Sinuses and Ears
  • Constipation
  • Stomach pain
  • Seizure
  • Headache
  • Dizziness
  • Stuffy / Runny Nose
  • change in personality
  • Low White Cell Count
  • High Fat Content in Blood

Infections, anemia, anorexia, hyperglycemia, hyperlipidemia, headache, pneumonitis, epistaxis, GI disorders.

Most common reason of inability to remain on Everolimus was irritation of Mucous Membranes. Mucous Membranes an epithelial tissue that secretes mucus and that lines many body cavities and tubular organs including the gut and respiratory passages. - mouth or on the genitals.

3. Other Uses

  • Advanced Kidney Cancer
  • Renal Transplantorgan Rejection Prevention
  • Subependymal Giant Cell Astrocytoma (SEGA)
  • Progressive / Metastatic Pancreatic Neuroendocrine Tumors
  • Breast Cancer

Sources