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Everolimus (Afinitor™)

Last Updated: 01/30/20

Status: Currently a NF2 Clinical Trial

Chemical Structure, RAD001

Trade Name:
Afinitor™ FermentekTM
RAD-001, RAD001, Certican, Afinitor, Zortress, Sirolimus,
SDZ-RAD, RAD001, Everolimus [USAN], RAD 001, Rapamycin,
42-O-(2-hydroxyethyl)-, UNII-9HW64Q8G6G
Pharmaceutical Company:
Legal Status:
℞ - Trial
Administered By:
Pill - Oral
Tumor Target:
Vestibular Schwannoma
Protein Target:
mTOR Inhibitors - specifically mTORC1
NF2 Trials

Side Effects

Infections, anemia, anorexia, hyperglycemia, hyperlipidemia, headache, pneumonitis, epistaxis, GI disorders.

Most common reason of inability to remain on Everolimus was irritation of mucous membranes. Mucous membranes an epithelial tissue that secretes mucus and that lines many body cavities and tubular organs including the gut and respiratory passages. - mouth or on the genitals.

Common Side Effects

  • Lung and Breathing Problems
  • Infections
  • Kidney Failure
  • Mouth and Vaginal Ulcers
  • Liver problems
  • Vaccinations - patients should not have live vaccinations while on Afinitor
  • Contraindicated with certain medications and certain foods

Additional Possible Side Effects:

  • Feeling Weak
  • Cough
  • Shortness of Breath
  • Diarrhea
  • Rash, Dry Skin, Itching
  • Nausea and Vomiting
  • Fever
  • Loss of Appetite
  • Swelling - Arms, Legs, Feet or Ankles
  • Infections - Respiratory Tract, Sinuses and Ears
  • Constipation
  • Stomach pain
  • Seizure
  • Headache
  • Dizziness
  • Stuffy / Runny Nose
  • change in personality
  • Low White Cell Count
  • High Fat Content in Blood

Other Uses

  • Advanced Kidney Cancer
  • Renal Transplantorgan Rejection Prevention
  • Subependymal Giant Cell Astrocytoma (SEGA)
  • Progressive / Metastatic Pancreatic Neuroendocrine Tumors
  • Breast Cancer


Everolimus or similar may be neded for management of skin irritation


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