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Tumor-Drug Treatments and Premature Ovarian Failure

Last Updated: 03/25/18


  • Tests and Prevention
  • POF Health Issues

Bevacizumab (Avastin™) is one of the tumor-drug treatments for NF2 currently in trials. One of the side effects of Avastin and other drug-tumor treatments is an increased length of Menstrual Cycles of over twenty-eight (28) days. Over time this can lead to lead to Premature Ovarian Failure (POF). While most females return to normal Menstrual Cycles after discontinuing use of the tumor-drug treatment, it is important to know the risks to take measures in prevention and monitor the health of ovaries.

Menopause is Ovarian Failure over the age of fifty (50). POF is when it happened to individuals earlier like it can because of on Avastin, which can happen to females in early teens. Early onset of Ovarian Failure, POF, results in serious health issues.

It is unknown why this has been seen commonly with individuals on drug-tumor treatments, then when taken for other reasons of use for Cancers. Oncologists who offer drug-tumor treatments may not know the risk and tests to prevent POF.

Tests and Prevention

When taking a drug-tumor treatment, it is necessary to test Estradiol Levels and FSH (Follicle-Stimulating Hormone) to monitor the health status of Ovaries. Taking Birth Control Pills can aid in regulating menstrual cycle to help prevent POF.

POF Health Issues

Premature Ovarian Failure can result in:

  • Increased risk of Heart Disease
  • Early Osteoporosis: Decreased bone density due to an insufficiency of Estrogen.
  • Amenorrhoea: Amenorrhoeas is a condition where an established menstruation has ceased for three months in a woman with a history of regular cyclic bleeding or nine months in a woman with a history of irregular periods.
  • Amenorrhoea Issues: Amenorrhoea causes serious pain in the back near the pelvis and spine. This pain has no cure, but can be relieved by a short course of Progesterone to trigger menstrual bleeding.

  • Hypothyroidism: A state in which the thyroid gland does not make enough thyroid hormone. Hypothyroidism can develop into Hashimoto's Thyroiditis, Addison's Disease, and other Autoimmune Disorders.
    • Hashimoto's Thyroiditis
    • Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease in which the thyroid gland is attacked by a variety of cell and antibody mediated immune processes.

      Hashimoto's Thyroiditis Issues; Weight gain, depression, mania, sensitivity to heat and cold, paresthesia, fatigue, panic attacks, bradycardia, tachycardia, high cholesterol, reactive hypoglycemia, constipation, migraines, muscle weakness, cramps, memory loss, infertility, and hair loss.

    • Addison's Disease
    • Addison's Disease, also known as Chronic Adrenal Insufficiency, Hypocortisolism, and Hypoadrenalism, is a condition where the Adrenal Glands do not produce sufficient steroid hormones.

      Addison's Issues: Addison's Disease would result in abdominal pain and weakness, but under certain circumstances, these may progress to Addisonian Crisis, a severe illness which may include very low blood pressure, and coma.