Neurofibromatosis (NF): NF1, NF2 and Schwannomatosis, are a genetic Autosomal Dominant conditions, which means each child a parent with NF1, NF2 or Schwannomatosis male or female has a 50% chance to born with the form of NF their parent has.
A Sporadic Mutation, which is the development of a condition neither parent had, is common development of NF. First generation NF can be a mild mutation in comparison to future generations, depending when in prenatal development that damaged cells from NF started to develop in the cells of a unborn child. NF can occur when sperm meets egg even if neither parent had NF, but if the genetic damage occurs after that, it would be a segmented mutation, also known as Mosaic or DeNuvo mutation. Mosaic NF can be less harmful to a person than someone who is born with damaged cells in their whole body, as their children who would be at risk would have.
A child born of an individual with NF1 or NF2 is at a risk of a more harmful case of NF than their parent. This is different for a yet to be determined reason, for people with Schwannomatosis, where they can be born with Schwannomatosis and not show any symptoms.
Development of NF; NF1, NF2 and Schwannomatosis are random mutations on different Chromosomes depending on the form of NF: