|Synonyms:||DB11727, Endostar, Endostatin, N-terminal-MGGSHHHHH|
|Legal Status:||℞ - Prescription/Pre-Clinical Trial|
|Tumor Target:||Schwannoma and Solid Tumors|
|Protein Target:||bFGF/FGF-2 and VEGF|
|NF2 Trials||Active, Not Recruiting: NCT02104323|
Endostatin: A protein which inhibits the formation of the blood vessels that supply tumours.
In-vitro studies have shown endostatin blocks the proliferation and organization of endothelial cells into new blood vessels. In animal studies endostatin inhibited angiogenesis and growth of both primary tumors and secondary metastasis.