CAPE Propolis

Last Updated: 04/17/17

Status: Alternative Treatment


Table of Contents

  1. Manuka Tree
  2. Warning / Safety
  3. NF2 Studies
  4. Related Articles
  5. Ordering Propolis from Manuka Health
  6. Different Forms of BIO30™ (Propolis)
  7. Dose
  8. Reference Sources
Trade Name BIO30™, BIO100™
Pharmaceutical Company Manuka Health
Dr. Welling (OSU) Not Effective Enough
Inhibitor Kinase PAK1
CAPE (Caffeic Acid Phenethyl Ester) and Antibacterial
Source New Zealand: Manuka Tree Honey

Studies have found that Propolis, a substance made from bee pollen from New Zealand, is rich in vitamins, bioflavonoids and phenolic acids, in addition to CAPE (Caffeic Acid Phenethyl Ester). Propolis in this form is an effective treatment in blocking Kinase PAK1. BIO30 could mean the prevention of further tumor growth in individuals with NF1 or NF2.

Manuka Tree

Propolis is honey made by bees from the flowering Manuka Tree and is the reason it is region specific. Propolis is available from additional sources throughout the world outside of New Zealand. Due to less access for bees to the Manuka Tree outside of New Zealand, those sources have inconsistent levels of CAPE and are less effective.

Warning / Safety

  • Children Bacteria: Honey can contain a bacterium that causes infant botulism, but would be safe for children over 12 months old. Under 12 months any food or medication that contains honey should be avoided, this concern would apply to CAPE Propolis.[American Academy of Pediatrics] Other sources suggest avoiding honey for children under the age of two or even three years old.
  • Bacteria Adults: It is possible in all honey products in any part of the world, and bacteria can be treated with an antibiotic. In one incident of bacterial infection for one individual with NF2, the individual had noted it as a stomach issue that needed to be treated by a doctor.
  • Allergies: If you are allergic to Honeybees of Pollen, you may want or take the first few doses with an allergy medication on hand if necessary.
  • Dose: Take the dose Manuka suggests to take. Do not take more than recommended dose.

NF2 Studies

Scientific testing through mice trials at Ohio State University, Doctor Welling, found CAPE to not be strong enough even in high doses to be more effective than stability at best for treatment of NF2.

A study within the NF2 community did reach a similar conclusion of this supplement helping to stabilize tumors for some individuals. However not all individuals had a similar experience of stability, some had continued growth. Individuals who had stability could have been unrelated to Propolis. Individuals, who experienced growth, could have been at an increased growth point with Propolis simply not being effective enough. This trial was too informal and did not include enough individuals for a proper conclusion.

More studies are needed to learn and confirm or disprove this as a medical treatment. It will help in the prevention of further damage to the different tumor types, which develop in individuals with NF1 and NF2.

Ordering Propolis from Manuka Health

Manuka Health - Propolis (BIO30™) - Liquid

To order Propolis from Manuka send an email to Annette Mention you would be taking it for NF2, and she will help suggest dose and process your order.

Or Order Direct from Manuka Honey

Different Forms of Propolis

  • Capsules (BIO100™): Due to unpleasant taste and to save time, purchase of capsules can help. Manuka Propolis is a higher concentration of CAPE.
  • Liquid (BIO30™): Since Propolis does not have a pleasant taste, purchase empty gel capsules Size 00, fill liquid into Capsules and freeze to prevent Propolis from leaking.
    • Additional Suggestions:
      Use a container for the pills to stand upright while stored to prevent leaking, like a craft or electronic storage box.
    • Make a container from:
      • Green Floral Foam works better than regular white foam.
      • Container of Rice or Sand
      • Also, try adding Propolis to Orange Juice or Coffee, the acidity can help kill the flavor of the Propolis.
  • Tablets: Avoid, tablets are not as effective as a liquid form of Propolis.


  • The dose to take is based on weight, the suggestion is 1ml for each 22lbs of your weight. So 5ml per day if your weight is 110lbs.
  • Ideally, your full dose should be separated to be taken during the day.

Reference Sources

  1. Gromisch, Maryann. Livestrong. "The Dangers and Benefits of Raw Honey" (Nov 10, 2016)
  2. Korioth, Trisha. American Academy of Pediatrics. "Simple remedies often best for common colds in young children" (2011)
  3. PubMed. The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity. (July 2012)
  4. PubMed. The anticancer activity of propolis. (April 2012)
  5. PubMed. CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. (December 2011)
  6. PubMed. Propolis. (Feb 2009)
What is NF2? | About Us | Treatment Options | Sitemap

Disclaimer: Neurofibromatosis Type 2 - Information and Services,, is not run by medical experts, affiliated with any healthcare organization or any other company. No assurance can be made to the accuracy or completeness of the information provided here, the accuracy of other sites to which this site links, or of sites that link to this site. - Read More

Copyright © 2008 - 2017