Home > Treatment Options > Tumor Suppressors > Clinical Trials >

rec-2282 (AR-42)

Last Updated: 08/28/20

Status: Unknown


Chemical Structure, AR42

Synonyms:
AR42, OSU-HDAR42, HDAR42,
N-hydroxy-4-(3-methyl-2-phenylbutyrylamino) benzamide
Pharmaceutical Company:
Arno Therapeutics
Legal Status:
℞ - Prescription/Under Clinical Trial
Administered By:
Pill - Oral
Tumor Target:
Meningioma and Schwannoma
Protein Target:
HDACi Inhibitor
NF2 Trials
Recruiting Trial: NCT02282917
Formula:
C18 H20 N2 O3
Chemical Name:
(S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide

Other Uses

Complete list of other health issues Ohio State University Comprehensive Cancer Center is testing AR-42 on.




NF2 Related Trials

AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma. - ClinicalTrials.gov NCT01129193

Phase 1

  • Adult Nasal Type Extranodal NK/T-cell Lymphoma
  • Anaplastic Large Cell Lymphoma
  • Angioimmunoblastic T-cell Lymphoma
  • Cutaneous B-cell Non-Hodgkin Lymphoma
  • Extranodal Marginal Zone B-cell Lymphoma of
    Mucosa-associated Lymphoid Tissue
  • Hepatosplenic T-cell Lymphoma
  • Intraocular Lymphoma
  • Nodal Marginal Zone B-cell Lymphoma
  • Peripheral T-cell Lymphoma
  • Post-transplant Lymphoproliferative Disorder
  • Prolymphocytic Leukemia
  • Recurrent Adult Burkitt Lymphoma
  • Recurrent Adult Diffuse Large Cell Lymphoma
  • Recurrent Adult Diffuse Mixed Cell Lymphoma
  • Recurrent Adult Diffuse Small Cleaved Cell Lymphoma
  • Recurrent Adult Grade III Lymphomatoid Granulomatosis
  • Recurrent Adult Hodgkin Lymphoma
  • Recurrent Adult Immunoblastic Large Cell Lymphoma
  • Recurrent Adult Lymphoblastic Lymphoma
  • Recurrent Adult T-cell Leukemia/Lymphoma
  • Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma
  • Recurrent Grade 1 Follicular Lymphoma
  • Recurrent Grade 2 Follicular Lymphoma
  • Recurrent Grade 3 Follicular Lymphoma
  • Recurrent Mantle Cell Lymphoma
  • Recurrent Marginal Zone Lymphoma
  • Recurrent Mycosis Fungoides/Sezary Syndrome
  • Recurrent Small Lymphocytic Lymphoma
  • Refractory Chronic Lymphocytic Leukemia
  • Refractory Multiple Myeloma
  • Stage III Adult Burkitt Lymphoma
  • Stage III Adult Diffuse Large Cell Lymphoma
  • Stage III Adult Diffuse Mixed Cell Lymphoma
  • Stage III Adult Diffuse Small Cleaved Cell Lymphoma
  • Stage III Adult Hodgkin Lymphoma
  • Stage III Adult Immunoblastic Large Cell Lymphoma
  • Stage III Adult Lymphoblastic Lymphoma
  • Stage III Adult T-cell Leukemia/Lymphoma
  • Stage III Chronic Lymphocytic Leukemia
  • Stage III Cutaneous T-cell Non-Hodgkin Lymphoma
  • Stage III Grade 1 Follicular Lymphoma
  • Stage III Grade 2 Follicular Lymphoma
  • Stage III Grade 3 Follicular Lymphoma
  • Stage III Mantle Cell Lymphoma
  • Stage III Marginal Zone Lymphoma
  • Stage III Multiple Myeloma
  • Stage III Mycosis Fungoides/Sezary Syndrome
  • Stage III Small Lymphocytic Lymphoma
  • Stage IV Adult Burkitt Lymphoma
  • Stage IV Adult Diffuse Large Cell Lymphoma
  • Stage IV Adult Diffuse Mixed Cell Lymphoma
  • Stage IV Adult Diffuse Small Cleaved Cell Lymphoma
  • Stage IV Adult Hodgkin Lymphoma
  • Stage IV Adult Immunoblastic Large Cell Lymphoma
  • Stage IV Adult Lymphoblastic Lymphoma
  • Stage IV Adult T-cell Leukemia/Lymphoma
  • Stage IV Chronic Lymphocytic Leukemia
  • Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma
  • Stage IV Grade 1 Follicular Lymphoma
  • Stage IV Grade 2 Follicular Lymphoma
  • Stage IV Grade 3 Follicular Lymphoma
  • Stage IV Mantle Cell Lymphoma
  • Stage IV Marginal Zone Lymphoma
  • Stage IV Mycosis Fungoides/Sezary Syndrome
  • Stage IV Small Lymphocytic Lymphoma
  • Testicular Lymphoma
  • Waldenstrom Macroglobulinemia

Sources

  • Burns, S. S., Akhmametyeva, E. M., Oblinger, J. L., Bush, M. L., Huang, J., Senner, V., ... & Chang, L. S. (2013). "Histone Deacetylase Inhibitor AR-42 Differentially Affects Cell-cycle Transit in Meningeal and Meningioma Cells, Potently Inhibiting NF2-Deficient Meningioma Growth." Cancer Research, 73(2), 792-803. Source: http://cancerres.aacrjournals.org/content/73/2/792.short | DOI: 10.1158/0008-5472.CAN-12-1888
  • Wang, G. H., Jiang, F. Q., Duan, Y. H., Zeng, Z. P., Chen, F., Dai, Y., ... & Zhang, X. K. (2013). "Targeting Truncated Retinoid X Receptor-a by CF31 Induces TNF-a-Dependent Apoptosis." Cancer research, 73(1), 307-318. Source: http://cancerres.aacrjournals.org/content/73/1/307.short
  • Bush ML; Oblinger J; Brendel V; Santarelli G; Huang J; Akhmametyeva EM; Burns SS; Wheeler J; Davis J; Yates CW; Chaudhury AR; Kulp S; Chen CS; Chang LS; Welling DB; Jacob A. "AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas.." Neuro-Oncology. Vol. 13, no. 9. (September 2011.): 983-. Source: http://neuro-oncology.oxfordjournals.org/content/13/9/983.short]
  • Xu, Weihong, et al. "The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production." Biochemical and biophysical research communications 463.4 (2015): 545-550. Source: https://www.sciencedirect.com/science/article/abs/pii/S0006291X15300048
  • CSID: 5293992, http://www.chemspider.com/Chemical-Structure.5293992.html (accessed 20:22, Nov 19, 2017)
  • "Navigating into the chemical space between MGCD0103 and SAHA: novel histone deacetylase inhibitors as a promising lead." MedChemCom (2015) Source: https://pubs.rsc.org/en/content/articlelanding/2015/md/c5md00247h/unauth#!divAbstract DOI: 10.1039/C5MD00247H
What is NF2? | About Us | Treatment Options | Sitemap

Site Search

Disclaimer: Neurofibromatosis Type 2 - Information and Services, www.nf2is.org, is not run by medical experts, affiliated with any healthcare organization or any other company. No assurance can be made to the accuracy or completeness of the information provided here, the accuracy of other sites to which this site links, or of sites that link to this site. - Read More

Copyright © 2021