Home > Treatment Options > Tumor Suppressors > Clinical Trials >

Mifepristone (RU-482)

Last Updated: 03/6/19


Chemical Structure, Mifepristone, RU-482

Index

  1. Status
  2. Tumor Target
  3. Class
  4. Class

Status: Phase 0 - NF2 Pre-Clinical

Tumor Target: Vestibular Schwannoma (VS)

Class: Progesterone Receptor Antagonist

Massachusetts Eye and Ear researchers have shown that Mifepristone (RU-482), a drug currently FDA-approved for chemical abortion, can also prevent the growth of vestibular schwannoma.

"Adverse effects for mifepristone include mild fatigue, hot flashes, nausea and rash. Long-term use of mifepristone has been studied in clinical trials for other tumors, with minimal adverse effects reported after years of usage.[1]

"Side Effects; nausea, vomiting, diarrhea, weakness, or dizziness may occur. Serious side effects; fever of 100.4 degrees F (38 degrees C) or higher, fainting, fast heartbeat, stomach/abdominal pain or tenderness."[5]

Sources

  1. Massachusetts Eye and Ear. "Mifepristone may halt growth of intracranial tumor that causes hearing loss." (2018)
    Source: https://www.masseyeandear.org/news/press-releases/2018/04/mifepristone-may-halt-growth-of-intracranial-tumor-that-causes- hearing-loss
  2. Nature. "Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma."(2018)
    Source: https://www.nature.com/articles/s41598-018-23609-7
  3. FDA. "Mifeprex (mifepristone) Information" (2018)
    Source: https://www.fda.gov/Drugs/DrugSafety/ucm111323.htm
  4. ScienceDaily. "Mifepristone may halt growth of intracranial tumor that causes hearing loss." (2018)
    Source: https://www.sciencedaily.com/releases/2018/04/180403115950.htm
  5. WebMD. "Mifepristone Tablet" (2018)
    Source: https://www.webmd.com/drugs/2/drug-20222-325/mifepristone-oral/mifepristone-oral/details
  6. ChemSpider. "Mifepristone."
    Source: http://www.chemspider.com/Chemical-Structure.49889.html
What is NF2? | About Us | Treatment Options | Sitemap

Disclaimer: Neurofibromatosis Type 2 - Information and Services, www.nf2is.org, is not run by medical experts, affiliated with any healthcare organization or any other company. No assurance can be made to the accuracy or completeness of the information provided here, the accuracy of other sites to which this site links, or of sites that link to this site. - Read More

Copyright © 2008 - 2019