Avastin and Premature Ovarian Failure

Index:

  • Tests and Prevention
  • POF Health Issues

Avastin is one of the tumor suppressor treatments for NF2 currently in trials. One of the side effects of Avastin is delayed menstrual periods which can lead to Premature Ovarian Failure (POF). For women who are taking Avastin, unless they develop POF, typically their cycle restarts after stopping Avastin, though it can take time to change back to its natural cycle.

Menopause, Ovarian Failure over the age of 50 is typical for women to experience. However, when Ovarian Failure occurs earlier and Premature Ovarian Failure (POF) develops, it results in serious health issues.

Tests and Prevention

While taking Avastin, Estradiol Levels and FSH (Follicle-Stimulating Hormone) should be checked to check health status of Ovaries. Taking Birth Control Pills can aid in regulating menstrual cycle to help prevent POF.

POF Health Issues

Premature Ovarian Failure can result in:

  • Increased risk of Heart Disease
  • Early Osteoporosis: Decreased bone density due to an insufficiency of Estrogen.
  • Amenorrhoea: Amenorrhoeas is a condition where an established menstruation has ceased for three months in a woman with a history of regular cyclic bleeding, or nine months in a woman with a history of irregular periods.
  • Amenorrhoea Issues: Amenorrhoea causes serious pain in the back near the pelvis and spine. This pain has no cure, but can be relieved by a short course of Progesterone to trigger menstrual bleeding.

  • Hypothyroidism: A state in which the thyroid gland does not make enough thyroid hormone. Hypothyroidism can develop into Hashimoto's Thyroiditis, Addison's Disease and other Auto-immune Disorders.
    • Hashimoto's Thyroiditis
    • Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease in which the thyroid gland is attacked by a variety of cell and antibody mediated immune processes.

      Hashimoto's Thyroiditis Issues; Weight gain, depression, mania, sensitivity to heat and cold, paresthesia, fatigue, panic attacks, bradycardia, tachycardia, high cholesterol, reactive hypoglycemia, constipation, migraines, muscle weakness, cramps, memory loss, infertility and hair loss.

    • Addison's Disease
    • Addison's Disease, also known as Chronic Adrenal Insufficiency, Hypocortisolism, and Hypoadrenalism, is a condition where the Adrenal Glands do not produce sufficient steroid hormones.

      Addison's Issues: Addison's Disease would result in abdominal pain and weakness, but under certain circumstances, these may progress to Addisonian Crisis, a severe illness which may include very low blood pressure and coma.

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