Crizotinib (Xalkori™)

  • Trial Availability: USA
  • Tumor Target: Recurrent Meningioma
  • Treatment by: Pill - Oral
  • Recruiting Trial: NCT02465060

PI3K/Akt/mTOR signaling pathway
Mammalian target of rapamycin (mTOR) serine/threonine kinase (dual mTOR Complex 1 and 2 inhibitor, mTORC1 and mTORC2) Synonym: PF-02341066
Chemical Formula: C21H22Cl2FN5O
Synonym: PF02341066; PF-02341066; PF 02341066; PF2341066; PF-2341066; PF 2341066; Crizotinib; US brand name: Xalkori;
IUPAC/Chemical Name: (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
Solubility: Soluble in DMSO, not in water. Dimethyl Sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO.
Inhibitor: inhibits the membrane receptor MET and activation of the MET signaling pathway
Side Effects: fatigue, nausea, mucositis, rash, constipation, vomiting, dyspnea and cough
Also In Use For: Breast Cancer, solid tumor cancer
Dose: Single doses up to 100 mg two times a day, but study duration 1 month
http://www.medkoo.com/products/4537
https://ncats.nih.gov/files/AZD2014.pdf
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