Boswellia

Last Updated: 04/14/14

(5LOX Inhibitor with ApresFlex™)

5LoxinThere is no financial profit to NF2 Information and Services, for sharing information from this product or source.

Table of Contents

  1. Classification
  2. Method
  3. Other Similar Drug Options
  4. Conditions Boswellia is Used to Treat
  5. Studies
  6. Conditions
  7. Side Effects - Warning and Suggestions
  8. Prescription Conflicts
  9. PubMed - Medical Articles for
    Boswellia / 5-LOXIN
  10. Link to Full Source Document
  11. Product Link

Boswellia, also known as Indian Frankincense, is an extract from the Boswellia Serrata tree. It is a family of medicine plants grown and used in India, Africa, China, and the Middle East.

Boswellia is a known effective anti-inflammatory. The most effective forms of Boswellia contains high concentration of ABKA (Acetyl Keto β Boswellic Acid), and LOX 5-LOXIN, also know as 5-LO, 5-LOX or 5-lipoxygenase. Boswellia has been used to treat inflammation causing illnesses for thousands of years. Structure: C30H48O3

Classification Anti-inflammatory - Similar to Prednisone

Method

5-LOX itself, creates Leukotrienes that promote conditions such as Cancer, Asthma, Atherosclerosis and other disease processes. 5-LOXIN, which blocks the 5-lipoxygenase (5-LOX) Enzyme, is a dangerous inflammatory enzyme.

Other Similar Drug Options

5-LOXIN is found to be safer then NSAIDs (Nonsteroidal Anti-inflammatory) Drugs such as Ibuprofen and Aspirin. While NSAIDs are good for immediate pain relief they can not be taken long term. Long term NSAIDs also inhibit the COX-enzyme, which are harmful to the stomach. Issues would include stomach irritation, bleeding, kidney toxicity, and / or peptie ulcers.

Conditions Boswellia is Used to Treat

While studies are underway for its use as a treatment for Breast Cancer, Leukemia and other tumors Boswellia is used as a for the following:

  • osteoarthritis
  • rheumatoid arthritis (RA)
  • asthma
  • inflammatory bowel disease
  • pain management

Studies

In an encouraging recent study of 5-LOXIN, where cell tracking techniques were utilized, proved that tumor cells lost their ability to metastasize and resulted in cell death in the same cells, by way of Apoptosis.

For NF2 (Neurofibromatosis Type 2), research is already underway of Boswellia, in Ohio State University under Dr Welling. More information on that can be found in the Transcript of Rachelle Swafford's Memorial and Brad Welling, MD, PhD Presentation at the Ohio Gathering

Conditions

Studies have proven that 5-LOXIN relieves symptoms for arthritis and inflammatory bowel disease. 5-LOXIN is also found to be effective against heart disease and some forms of Cancer. It is better in some cases than Chemotherapy and have been found to be effective in Meningioma cells as well.

Side Effects - Warning and Suggestions

Bostwllia / 5-LOXIN, is safe and well tolerated with no noted side effects listed in documentation. However, as a form of steroids, this might be an issue and surgery will then be necessary. Make sure your doctor knows you are taking this and at what dose.

Prescription Conflicts

It is important to check conflicts there might be with other prescription medication you might be taking. If the doctor prescribing your other medications is not familiar with Bosweilla, you might want to ask about conflicts there might be with Prednisone since it is the closest medication to compare it to.

PubMed - Medical Articles on Boswellia / 5-LOXIN from Respected Sources

Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells
Date: December 15, 2011 Source: PubMed
"Gum resins obtained from trees of the Burseraceae family (Boswellia sp.) are important ingredients in incense and perfumes. Extracts prepared from Boswellia sp. gum resins have been shown to possess anti-inflammatory and anti-neoplastic effects. Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells."
Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets
Date: October 31, 2011Source: PubMed
"AKBA produced significant decreases in the expression of NF-?B regulating genes in the tissues. Immunohistochemical analysis also showed AKBA downregulated the expression of COX-2, MMP-9, CXCR4, and VEGF in the tissues. Overall these results demonstrate that AKBA can suppress the growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model that correlates with modulation of multiple targets."
Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers
Date: June 23, 2011 Source: PubMed
"Numerous cancer therapeutics were originally identified from natural products used in traditional medicine. One such agent is acetyl-11-keto-beta-boswellic acid (AKBA), derived from the gum resin of the Boswellia serrata known as Salai guggal or Indian frankincense. Traditionally, it has been used in Ayurvedic medicine to treat proinflammatory conditions. In this report, we hypothesized that AKBA can affect the growth and metastasis of colorectal cancer (CRC) in orthotopically implanted tumors in nude mice. We found that the oral administration of AKBA (50-200 mg/kg) dose-dependently inhibited the growth of CRC tumors in mice, resulting in decrease in tumor volumes than those seen in vehicle-treated mice without significant decreases in body weight."
"Thus, our findings suggest that this boswellic acid analog can inhibit the growth and metastasis of human CRC (colorectal cancer) in vivo through downregulation of cancer-associated biomarkers."
Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse
Date: April 12, 2011 Source: PubMed
"Boswellic acid (BA), a triterpene, isolated from Boswellia serrata (Burseraceae) has been found to possess potent anti-inflammatory and anti-cancer activity."
"The treatments also increased the survival of tumor-bearing mice."
"The present study sheds light on the potent antitumor property of the boswellic acid and can be extended further to develop therapeutic protocols for treatment of cancer."
Additional PubMed Articles on Bosweilla and Tumors

Link to Full Document

Ancient Herb - Suppresses Inflammation Document contains additional research facts and citations by researchers and scientists.

Product Link - 5-LOX Inhibitor with AprèsFlex™




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