Boswellia, also known as Indian Frankincense, is an extract from the Boswellia Serrata tree. It is a family of medicine plants grown and used in India, Africa, China, and the Middle East.
Boswellia is a known effective anti-inflammatory. The most effective forms of Boswellia contains high concentration of ABKA (Acetyl Keto β Boswellic Acid), and LOX 5-LOXIN, also know as 5-LO, 5-LOX or 5-lipoxygenase. Boswellia has been used to treat inflammation causing illnesses for thousands of years. Structure: C30H48O3
5-LOX itself, creates Leukotrienes that promote conditions such as Cancer, Asthma, Atherosclerosis and other disease processes. 5-LOXIN, which blocks the 5-lipoxygenase (5-LOX) Enzyme, is a dangerous inflammatory enzyme.
5-LOXIN is found to be safer then NSAIDs (Nonsteroidal Anti-inflammatory) Drugs such as Ibuprofen and Aspirin. While NSAIDs are good for immediate pain relief they can not be taken long term. Long term NSAIDs also inhibit the COX-enzyme, which are harmful to the stomach. Issues would include stomach irritation, bleeding, kidney toxicity, and / or peptie ulcers.
While more studies are underway, 5-LOXIN has had some study results indicating that it is effective in issues as severe as Heart Disease, Breast Cancer, Leukemia, Meningioma cells, and other possible tumors and Cancer types. Research suggests 5-LOXIN has advantages over Chemotherapy. Boswellia is otherwise used as a treatment for the following:
In an encouraging recent study of 5-LOXIN, where cell tracking techniques were utilized, proved that tumor cells lost their ability to metastasize and resulted in cell death in the same cells, by way of Apoptosis.
For NF2 (Neurofibromatosis Type 2), research is already underway of Boswellia, in Ohio State University under Dr. Welling. More information on that can be found in the Transcript of Rachelle Swafford's Memorial and Brad Welling, MD, PhD Presentation at the Ohio Gathering
Bostwllia / 5-LOXIN, is safe and well tolerated with no noted side effects listed in documentation. However, as a form of steroids, this might be an issue and surgery will then be necessary. Make sure your doctor knows you are taking this and at what dose.
It is important to check conflicts there might be with other prescription medication you might be taking. If the doctor prescribing your other medications is not familiar with Bosweilla, you might want to ask about conflicts there might be with Prednisone since it is the closest medication to compare it to.
"Gum resins obtained from trees of the Burseraceae family (Boswellia sp.) are important ingredients in incense and perfumes. Extracts prepared from Boswellia sp. gum resins have been shown to possess anti-inflammatory and anti-neoplastic effects. Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells."
"AKBA produced significant decreases in the expression of NF-?B regulating genes in the tissues. Immunohistochemical analysis also showed AKBA downregulated the expression of COX-2, MMP-9, CXCR4, and VEGF in the tissues. Overall these results demonstrate that AKBA can suppress the growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model that correlates with modulation of multiple targets."
"Numerous cancer therapeutics were originally identified from natural products used in traditional medicine. One such agent is acetyl-11-keto-beta-boswellic acid (AKBA), derived from the gum resin of the Boswellia serrata known as Salai guggal or Indian frankincense. Traditionally, it has been used in Ayurvedic medicine to treat proinflammatory conditions. In this report, we hypothesized that AKBA can affect the growth and metastasis of colorectal cancer (CRC) in orthotopically implanted tumors in nude mice. We found that the oral administration of AKBA (50-200 mg/kg) dose-dependently inhibited the growth of CRC tumors in mice, resulting in decrease in tumor volumes than those seen in vehicle-treated mice without significant decreases in body weight."
"Thus, our findings suggest that this boswellic acid analog can inhibit the growth and metastasis of human CRC (colorectal cancer) in vivo through downregulation of cancer-associated biomarkers."
"Boswellic acid (BA), a triterpene, isolated from Boswellia serrata (Burseraceae) has been found to possess potent anti-inflammatory and anti-cancer activity."
"The treatments also increased the survival of tumor-bearing mice."
"The present study sheds light on the potent antitumor property of the boswellic acid and can be extended further to develop therapeutic protocols for treatment of cancer."
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